halopredone
halopredone Basic information
- Product Name:
- halopredone
- Synonyms:
-
- 2-Bromo-6β,9-difluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione
- halopredone
- Pregna-1,4-diene-3,20-dione, 2-bromo-6,9-difluoro-11,17,21-trihydroxy-, (6β,11β)-
- CAS:
- 57781-15-4
- MF:
- C21H25BrF2O5
- MW:
- 475.32
- EINECS:
- 260-953-5
- Mol File:
- 57781-15-4.mol
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halopredone Chemical Properties
- Boiling point:
- 611.8±55.0 °C(Predicted)
- Density
- 1.59±0.1 g/cm3(Predicted)
- pka
- 11.91±0.70(Predicted)
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halopredone Usage And Synthesis
Originator
Topicon,Pierrel,Italy,1983
Uses
Anti-inflammatory (topical).
Manufacturing Process
100 ml of a 70% hydrofluoric acid aqueous solution were cooled to -10°C in a polyethylene flask equipped with electromagnetic stirrer. 10 g of 2-bromo-6β- fluoro-17α,21-dihydroxy-9β, 11β-oxido-pregna-1,4-diene-3,20-dione-17,21- diacetate were added under stirring during 15 minutes. After 0.5 hour the reaction mixture was precipitated in water and ammonia. The solid was collected by filtration, washed with water and dried to a constant weight, giving about 9.5 g of 2-bromo-6β,9α-difluoro-11β,17α,21 -trihydroxypregna- 1,4-diene-3,20-dione-17,21-diacetate.
Therapeutic Function
Topical antiinflammatory