Basic information Safety Supplier Related

Dexamethasone sodium phosphate EP Impurity B

Basic information Safety Supplier Related

Dexamethasone sodium phosphate EP Impurity B Basic information

Product Name:
Dexamethasone sodium phosphate EP Impurity B
Synonyms:
  • 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(hydrogen phosphonate)
  • Betamethasone phosphate
  • Betamethasone 21-(dihydrogen phosphate)
  • Betamethasone 21-phosphate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16β)- (9CI)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate) (7CI, 8CI)
  • 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphate
  • 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphoric acid
CAS:
360-63-4
MF:
C22H30FO8P
MW:
472.44
EINECS:
206-636-7
Mol File:
360-63-4.mol
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Dexamethasone sodium phosphate EP Impurity B Usage And Synthesis

Originator

Bentelan,Biofutura

Uses

Glucocorticoid.

Manufacturing Process

A solution of bistriethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml, of triethylamine at 20°C. This solution was added to a stirred mixture of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for 4 h and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The salt of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene- 3,20-dione 21-phosphate may be converted to 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate by treatment with acid (for example HCl).

brand name

Celestone (Schering).

Therapeutic Function

Glucocorticoid

Dexamethasone sodium phosphate EP Impurity BSupplier

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