Dexamethasone sodium phosphate EP Impurity B
Dexamethasone sodium phosphate EP Impurity B Basic information
- Product Name:
- Dexamethasone sodium phosphate EP Impurity B
- Synonyms:
-
- 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(hydrogen phosphonate)
- Betamethasone phosphate
- Betamethasone 21-(dihydrogen phosphate)
- Betamethasone 21-phosphate
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16β)- (9CI)
- Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-(dihydrogen phosphate) (7CI, 8CI)
- 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphate
- 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-phosphoric acid
- CAS:
- 360-63-4
- MF:
- C22H30FO8P
- MW:
- 472.44
- EINECS:
- 206-636-7
- Mol File:
- 360-63-4.mol
Dexamethasone sodium phosphate EP Impurity B Usage And Synthesis
Originator
Bentelan,Biofutura
Uses
Glucocorticoid.
Definition
ChEBI: Betamethasone phosphate is a steroid phosphate that is the 21-O-phospho derivative of betamethasone. It has a role as an anti-inflammatory agent and an immunosuppressive agent. It is a steroid phosphate, an 11beta-hydroxy steroid, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone. It is a conjugate acid of a betamethasone phosphate(2-).
Manufacturing Process
A solution of bistriethylamine phosphate was prepared by slowly adding 2.36
ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml, of
triethylamine at 20°C. This solution was added to a stirred mixture of 4.70 g
of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
21-methanesulfonate and 20 ml of acetonitrile. The mixture was heated under
reflux for 4 h and then evaporated under reduced pressure to a volume of 12
ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate
triethylamine salt with some inorganic phosphate.
The salt of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-
3,20-dione 21-phosphate may be converted to 9α-fluoro-11β,17α,21-
trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate by
treatment with acid (for example HCl).
brand name
Celestone (Schering).
Therapeutic Function
Glucocorticoid
Dexamethasone sodium phosphate EP Impurity BSupplier
- Tel
- 025-58619198
- sales@mbbio.com
- Tel
- 010-56205725
- waley188@sohu.com
- Tel
- +86 21 61551611
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
- Tel
- 16314854226
- info@bocsci.com
Dexamethasone sodium phosphate EP Impurity B(360-63-4)Related Product Information
- 11-Keto Betamethasone
- 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate
- Betamethasone EP Impurity D
- Betamethasone Valerate EP Impurity I
- Betamethasone Impurity 8
- Betamethasone
- Dexamethasone 21-phosphate disodium salt
- Betamethasone Impurity 38
- 17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione
- Betamethasone Tripropionate
- BecloMethasone 17-Valerate
- Betamethasone Impurity 31
- Betamethasone EP Impurity H
- Betamethasone Impurity 32
- Betamethasone Impurity 35
- Betamethasone impurity 1
- Betamethasone Enol Aldehyde Z Isomer
- 1,2-Dihydro-BetaMethasone 17,21-Dipropionate