6-Iodoamiloride,hydrochloridedihydrate
6-Iodoamiloride,hydrochloridedihydrate Basic information
- Product Name:
- 6-Iodoamiloride,hydrochloridedihydrate
- Synonyms:
-
- 6-Iodoamiloride,HCldihydrate
- 6-iodoamiloride
- 3,5-Diamino-6-iodo-N-(aminoiminomethyl)pyrazine-2-carboxamide
- 2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-iodo-
- CAS:
- 60398-23-4
- MF:
- C6H8IN7O
- MW:
- 321.08
- Mol File:
- 60398-23-4.mol
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6-Iodoamiloride,hydrochloridedihydrate Usage And Synthesis
Uses
6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1].
References
[1] Rocio K Finol-Urdaneta, et al. Automated Patch Clamp Screening of Amiloride and 5- N, N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Mol Pharm. 2023 Jul 3;20(7):3367-3379. DOI:10.1021/acs.molpharmaceut.2c01083