Sulfinalol
Sulfinalol Basic information
- Product Name:
- Sulfinalol
- Synonyms:
-
- Sulfinalol
- 1-(4-Hydroxy-3-methylsulfinylphenyl)-6-(4-methoxyphenyl)-4-methyl-3-aza-1-hexanol
- 4-Hydroxy-alpha-(((3-(p-methoxyphenyl)-1-methylpropyl)amino)methyl)-3-(methylsulfinyl)benzyl alcohol
- 63251-39-8 (Hydrochloride)
- Benzenemethanol, 4-hydroxy-alpha-(((3-(4-methoxyphenyl)-1-methylpropyl)amino)methyl)-3-(methylsulfinyl)-
- Sulfinalol [inn]
- Sulfinalolum
- Sulfinalolum [inn-latin]
- CAS:
- 66264-77-5
- MF:
- C20H27NO4S
- MW:
- 377.5
- Mol File:
- 66264-77-5.mol
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Sulfinalol Usage And Synthesis
Uses
Sulfinalol is an orally active β-adrenoceptor antagonist with direct vasodilator activity[1].
Definition
ChEBI: Sulfinalol is a sulfoxide.
in vivo
Sulfinalol shows direct vasodilator activity and antihypertensive activity[1].
| Animal Model: | Mongrel dogs weighing 8.7-21.2 kg were anesthetized with pentobarbital (30-35 mg/kg, i.v., followed by a continuous infusion of 4 mg/kg/h)[1] |
| Dosage: | 0-100 μg |
| Administration: | Intraarterial injection |
| Result: | Increased blood flow in the sympathetically denervated hindlimb of anesthetized dogs. |
| Animal Model: | Male spontaneously hypertensive rats (SHR)[1] |
| Dosage: | 2.5 mg/kg |
| Administration: | Oral administration |
| Result: | Reduced pressure of conscious spontaneously hypertensive rats. |
IC 50
β-adrenoceptor
References
[1] E J Sybertz, et al. Studies on the mechanism of the acute antihypertensive and vasodilator actions of several beta-adrenoceptor antagonists. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):749-58. DOI:10.1097/00005344-198209000-00009