Ifetroban
Ifetroban Basic information
- Product Name:
- Ifetroban
- Synonyms:
-
- Ifetroban
- Benzenepropanoic acid, 2-[[(1S,2R,3S,4R)-3-[4-[(pentylamino)carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]-
- BMS 180291-02
- BMS180291
- BMS-180291
- CAS:
- 143443-90-7
- MF:
- C25H32N2O5
- MW:
- 440.537
- Mol File:
- 143443-90-7.mol
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Ifetroban Chemical Properties
- form
- Solid
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Ifetroban Usage And Synthesis
Uses
Antithrombotic.
Definition
ChEBI: Ifetroban is a monocarboxylic acid and a member of benzenes.
in vivo
Ifetroban (50 mg/kg/d; p.o.; 2 d prior to, through 28 d after tumor injection) decreases hematogenous metastasis of multiple cancer types without in mice model[2].
Ifetroban (50 mg/kg/d; p.o.; 12 d) does not affect primary tumor growth but decreases tumor vessels in mice with 4T1 (mouse mammary cancer)[2].
Ifetroban (BMS 180,291; 1 and 3 mg/kg, p.o.) inhibits aggregation and antagonizes TP-receptor in monekys. Ifetroban (3 mg/kg, i.v.) causes only marginal and transient hemodynamic effects in anesthetized African green monkeys[3].
| Animal Model: | Athymic (nu/nu) Balb/C female mice injected with tumor cells: 4T1 (mouse mammary cancer), MDA-MB-231 (human breast cancer), MiaPaCa2 (human pancreatic cancer), and A549 (human lung cancer) model[2] |
| Dosage: | 50 mg/kg; via 25 μL vehicle (4% sucrose in sterile water) |
| Administration: | Oral gavage; pretreated before 2 days and treated 28 days later |
| Result: | Decreased the percentage of mice harboring MDA-MB-231 lung metastases from 90% to 20%, and mice with A549 lung metastases from 60% to 10%. |
IC 50
TXA2/TP
IfetrobanSupplier
Jiangsu Magic Biotechnology Co., Ltd
- Tel
- 13921770081
- svp01@magicbiotech.cn
Zhengzhou Runkai Pharmaceutical Technology Co., Ltd
- Tel
- 191-19137044811 19137644811
- 3649307081@qq.com
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd
- Tel
- 19066311943
- 815989315@qq.com