S-Trityl-D-cysteine Chemical Properties

Boiling point:

524.7±50.0 °C(Predicted)

Density 

1.232±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

pka

2.22±0.10(Predicted)

form 

Solid

color 

White to off-white

optical activity

Consistent with structure

Water Solubility 

Sparingly soluble in water 0.022 g/L 25°C.

Safety Information

Risk Statements 

22

Safety Statements 

22-24/25

S-Trityl-D-cysteine Usage And Synthesis

Uses

(-)-S-Trityl-D-cysteine is used in medicine as intermediate. It inhibits the human mitotic kinesin Eg5.

Synthesis

General procedure for the synthesis of S-triphenylmethyl-L-cysteine from triphenylmethanol and D-cysteine: D-cysteine (242.30 mg, 2.0 mmol) was placed in a single-necked flask, trifluoroacetic acid (TFA, 4 mL) was added and stirred at room temperature. Triphenylmethanol (520.68 mg, 2.0 mmol) was then added and the reaction continued to be stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was cooled to 0 °C, anhydrous ether (30 mL) was added, and the pH was adjusted to 4-5 by slowly adding 4 N NaOH aqueous solution dropwise with stirring.Next, 10% saturated sodium acetate aqueous solution was added, and stirring was continued for 1 h to stabilize the pH at 5-6.The reaction mixture was filtered, and the filter cake was washed with anhydrous ether (30 mL × 2) to afford the white powdery product S Triphenylmethyl-L-cysteine (566.4 mg, yield: 77.90%).

References

[1] Patent: CN106432014, 2017, A. Location in patent: Paragraph 0199; 0200; 0201; 0202

S-Trityl-D-cysteine(25840-82-8)Related Product Information

• H-D-Cys(Trt)-OtBu·HCl
• H-D-Cys(Trt)-NH2
• H-D-Cys(Acm)-OMe·HCl
• H-D-CYS(ACM)-OH HCL
• 4-METHOXY-TRITYL-D-CYSTEINE
• FMOC-D-PEN(TRT)-OH
• N-Fmoc-S-trityl-D-cysteine
• S-Trityl-D-cysteine
• Fmoc-D-Cys(Trt)- OPfp
• FMOC-D-CYS(MMT)-OH
• N-Boc-S-Trityl-L-cysteine
• BOC-D-PEN(TRT)-OH
• H-D-PEN(TRT)-OH