6-methoxy-2-phenyl-tetralone Chemical Properties

Melting point:

113-116 °C

Boiling point:

429.9±45.0 °C(Predicted)

Density 

1.141±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder

color 

Yellow

Safety Information

HS Code 

2914500090

6-methoxy-2-phenyl-tetralone Usage And Synthesis

Synthesis

A Schlenk flask was charged with 6-methoxy-3,4-dihydronaphthalen-1(2H)-one (1,352 mg, 2.0 mmol), sodium tert-butanolate (365 mg, 3.8 mmol) and Pd-132 (1.4 mg, 0.002 mmol). The flask was sealed with a rubber stopper, evacuated three times and backfilled with nitrogen operation. Chlorobenzene (0.20 mL, 2.0 mmol) was added to the flask via a gas-tight syringe, followed by dioxane (2.0 mL). The reaction mixture was stirred at 100°C for 18 hours. After completion of the reaction, the mixture was filtered through a silica gel column and the silica gel pad was washed with methyl tert-butyl ether (MTBE, 20 mL). The filtrate was concentrated to give the off-white solid product 6-methoxy-2-phenyltetralone (455 mg, 90% yield). The structure of the product was confirmed by 1H NMR (CDCl3) and 13C NMR (CDCl3).

References

[1] Chemistry - A European Journal, 2014, vol. 20, # 52, p. 17272 - 17276
[2] Patent: WO2012/159981, 2012, A2. Location in patent: Page/Page column 20
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 34, p. 9012 - 9021

6-methoxy-2-phenyl-tetralone(1769-84-2)Related Product Information

• 6-METHOXY-2-METHYL-1-TETRALONE
• 6-methoxy-1-tetralone
• 6-methoxy-2-phenyl-tetralone