4-Amino-2-trifluoromethylpyridine Chemical Properties

Melting point:

58-62°C

Boiling point:

230.7±40.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder to crystal

pka

4.62±0.50(Predicted)

color 

White to Almost white

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

25-36-43

Safety Statements 

26-36/37

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29333990

4-Amino-2-trifluoromethylpyridine Usage And Synthesis

Chemical Properties

4-Amino-2-trifluoromethylpyridine can undergo a Chichibabin reaction to introduce an additional amine group in the para-position. It is employed in the synthesis of oral checkpoint kinase inhibitor for immunotherapy.

Uses

4-Amino-2-(trifluoromethyl)pyridine are involved in many syntheses of active pharmaceutical ingredients (APIs), such as naporafenib, a RAF inhibitor used in the treatment of RAF-driven cancers.

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