Basic information Safety Supplier Related

MONACOLIN J

Basic information Safety Supplier Related

MONACOLIN J Basic information

Product Name:
MONACOLIN J
Synonyms:
  • (4R,6R)-4-Hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one
  • 6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
  • (4R,6R)-
  • SiMvastatin Lactone Diol
  • Lovastatin Lactone Diol
  • Lovastatin Diol Lactone
  • Simvastatin EP Impurity H
  • Lovastatin Impurity 8
CAS:
79952-42-4
MF:
C19H28O4
MW:
320.42322
Product Categories:
  • Chiral Reagents
  • Drug Analogues
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
79952-42-4.mol
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MONACOLIN J Chemical Properties

Melting point:
50-53°C
Boiling point:
535.7±50.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform (Slightly), DMF, DMSO, Methanol (Slightly)
form 
Solid
pka
13.49±0.40(Predicted)
color 
White to Pale Yellow
Stability:
Hygroscopic
InChIKey
ZDFOBOYQVYMVCW-IRUSZSJRSA-N
SMILES
C1(=O)O[C@H](CC[C@@H]2[C@]3([H])C(=C[C@H](C)C[C@@H]3O)C=C[C@@H]2C)C[C@@H](O)C1
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MONACOLIN J Usage And Synthesis

Chemical Properties

Tan Solid

Uses

Monacolin J is a Simvastatin intermediate; Lovastatin analog has the activities of decreasing blood cholesterol and low-d. lipoprotein, can be used to preparation hypolipidemic medicine.

Definition

ChEBI: A polyketide that is monacolin L bearing an additional hydroxy substituent at position 8.

MONACOLIN JSupplier

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