Ristocetin Chemical Properties

alpha 

D -120 to -133° (water)

Density 

1.76±0.1 g/cm3(Predicted)

pka

8.55±0.70(Predicted)

Safety Information

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

mouse,LD50,intravenous,1350mg/kg (1350mg/kg),SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE,"Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 568, 1967.

Ristocetin Usage And Synthesis

Uses

Ristocetin A sulfate is a potent antibacterial glycopeptide antibiotic that was withdrawn from clinical use following a high incidence of thrombocytopenia. Further investigation found that ristocetin A induced platelet aggregation by binding to a factor absent in people suffering from von Willebrand's disease, leading to the use of ristocetin A as an important diagnostic aid.

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