Vatanidipine
Vatanidipine Basic information
- Product Name:
- Vatanidipine
- Synonyms:
-
- Vatanidipine
- AE0047
- 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[4-(4-benzhydryl-1-piperazinyl)phenethyl]5-methyl ester
- 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-[4-[(4-benzhydrylpiperazin)-1-yl]phenyl]ethyl] ester
- Watanidipine
- WATA-012
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-[4-(diphenylmethyl)-1-piperazinyl]phenyl]ethyl] 5-methyl ester
- Vatanidipine, 10 mM in DMSO
- CAS:
- 116308-55-5
- MF:
- C41H42N4O6
- MW:
- 686.805
- Mol File:
- 116308-55-5.mol
Vatanidipine Chemical Properties
- Boiling point:
- 799.4±60.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- pka
- 7.11±0.10(Predicted)
Vatanidipine Usage And Synthesis
Uses
Vatanidipine (Watanidipine) is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings[1][2].
in vivo
Vatanidipine (1-10 mg/kg, p.o.) suppresses the systolic blood pressure of spontaneously hypertensive rats[1].
References
[1] Matsumura Y, et al. Vatanidipine hydrochloride: a new long-lasting antihypertensive agent. Expert Opin Investig Drugs. 2001 Jan;10(1):139-55. DOI:10.1517/13543784.10.1.139
[2] H Shinyama, et al. Effects of the calcium antagonist AE0047 on the development of neurological deficit and infarction after middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Pharm Pharmacol. 1997 Sep;49(9):919-24. DOI:10.1111/j.2042-7158.1997.tb06136.x
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