4-PIPERAZINOPHENOL DIHYDROBROMIDE Chemical Properties

Melting point:

275 °C (decomp)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

36/37/39-26-22

RIDADR 

UN2811

HazardClass 

6.1

HS Code 

29335990

MSDS

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4-PIPERAZINOPHENOL DIHYDROBROMIDE Usage And Synthesis

Chemical Properties

off-white to light beige or light pink

Synthesis

The preparation process for 4-Piperazinophenol dihydrobromide is as follows: Step 1: Synthesis of Dibromoethylamine hydrobromide: React diethylamine with 40% hydrogen bromide. The mixture is heated, dehydrated by fractional distillation, and excess hydrogen bromide is removed by distillation. Acetone is then added to precipitate the crystals.

Step 2: Synthesis of 4-Methoxyphenylpiperazine Dibromide: The product from Step 1 is refluxed with p-Toluidine in n-Butanol. Anhydrous sodium carbonate powder is added. Crystals are obtained upon cooling.

Step 3: Synthesis of 4-hydroxyphenylpiperazine dihydrobromide: Heat the product from Step 2 with recovered 40% hydrogen bromide solution under reflux conditions, then perform fractional distillation. Continue distillation after raising the temperature. Concentrate the distillate and add acetone to precipitate the crystals.

4-PIPERAZINOPHENOL DIHYDROBROMIDE(38869-37-3)Related Product Information

• 2-ISOPROPYLANISOLE
• 4-PIPERAZINOPHENOL DIHYDROBROMIDE
• N-(4-HYDROXYPHENYL)PIPERAZINE-D8, DIHYDROBROMIDE
• 4-(dimethylamino)phenol
• 1-(4-Hydroxyphenyl)piperazine