L 652343
L 652343 Basic information
- Product Name:
- L 652343
- Synonyms:
-
- L 652343
- 343
- L 652
- L652
- L-652
- Benzo[b]thiophene-2-carboxamide, 3-hydroxy-N-[2-phenyl-2-(2-thienyl)ethenyl]-5-(trifluoromethyl)-, (E)- (9CI)
- CAS:
- 102565-09-3
- MF:
- C22H14F3NO2S2
- MW:
- 445.48
- Mol File:
- 102565-09-3.mol
L 652343 Chemical Properties
- Boiling point:
- 634.2±55.0 °C(Predicted)
- Density
- 1.436±0.06 g/cm3(Predicted)
- pka
- 6?+-.0.50(Predicted)
L 652343 Usage And Synthesis
Description
L 652343 is an inhibitor of cyclooxygenase and 5-lipoxygenase in vitro and inhibits the synthesis of the products of both these pathways in whole cells.
Uses
(E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer[1].
References
[1] Stereoselective disposition of the geometric isomers of a novel lipoxygenase cyclo-oxygenase inhibitor in dog and photochemical interconversion of its isomers