LY 25648
LY 25648 Basic information
- Product Name:
- LY 25648
- Synonyms:
-
- LY 25648
- Dihydro-3-methyl-5-(4-hydroxy-3,5-ditert-butylbenzylidene)thiazol-4(5H)-one
- LY-256548
- 4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-3-methyl-
- CAS:
- 107889-31-6
- MF:
- C19H27NO2S
- MW:
- 333.49
- Mol File:
- 107889-31-6.mol
LY 25648 Usage And Synthesis
Description
LY 25648 is a leukotriene B4 antagonist.
Uses
LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model[1][2].
in vivo
The oral absorption of LY256548 (LY25648) in rats, dogs, and monkeys was 45%, 7%, and 12%, respectively, and the systemic bioavailability was 6%, 0.4%, and 3%, respectively[1].
IC 50
Cyclooxygenase; 5-LOX; PLA2; LTB4
References
[1] Ruterbories KJ, et al. Pharmacokinetics of a novel butylated hydroxytoluene-thiazolidinone CNS antiischemic agent LY256548 in rats, mice, dogs, and monkeys. Drug Metab Dispos. 1990 Sep-Oct;18(5):674-9. PMID:1981719
[2] Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2. DOI:10.1007/BF01972804