LY 245769
LY 245769 Basic information
- Product Name:
- LY 245769
- Synonyms:
-
- LY 245769
- Benzenemethanol, 3-(1H-tetrazol-5-yl)-α-[(1R,2E,4Z)-14,14,14-trifluoro-1-[[2-(1H-tetrazol-5-yl)ethyl]thio]-2,4-tetradecadienyl]-, (αS)- (9CI)
- CAS:
- 127345-02-2
- MF:
- C25H33F3N8OS
- MW:
- 550.6427296
- Mol File:
- 127345-02-2.mol
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LY 245769 Chemical Properties
- Boiling point:
- 746.8±70.0 °C(Predicted)
- Density
- 1.286±0.06 g/cm3(Predicted)
- pka
- 4.23±0.10(Predicted)
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LY 245769 Usage And Synthesis
Description
LY 245769 is a leukotriene E4 (LTE4) inhibitor.
Uses
LY 245769, a omega-trifluoro analog, is a leukotriene E4 (LTE4) inhibitor. LY 245769 interfers the omega-oxidation of N-acetyl-LTE4 and leukotriene B4 (LTB4) with IC50s of 4 μM[1].
References
[1] G Jedlitschky, et al. Inhibition of leukotriene omega-oxidation by omega-trifluoro analogs of leukotrienes. Arch Biochem Biophys. 1990 Nov 1;282(2):333-9. DOI:10.1016/0003-9861(90)90125-i