BN 50730
BN 50730 Basic information
- Product Name:
- BN 50730
- Synonyms:
-
- BN 50730
- 4H-Pyrido(4',3'-4,5)thieno(3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine-9(8H)-carbothioamide, 6-(2-chlorophenyl)-7,10-dihydro-N-(4-methoxyphenyl)-1-methyl-
- 6-(2-Chlorophenyl)-9-((4-methoxyphenyl)thiocarbamoyl)-1-methyl-7,8,9,10-tetrahydro-4H-pyrido(4',3'-4,5)thieno(3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine
- PubChem ID: 3033963
- LAU 8080
- LAU8080
- LAU-8080
- CAS:
- 132579-32-9
- MF:
- C26H23ClN6OS2
- MW:
- 535.08
- Mol File:
- 132579-32-9.mol
BN 50730 Usage And Synthesis
Description
Rocepafant, also known as BN-50730; LAU-8080, is a platelet activating factor (PAF) antagonist potentially for the treatment of asthma. BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. BN 50730 also showed activity to inhibit tumor necrosis factor-alfa-mediated cytotoxicity on murine L929 tumor cells.
Uses
Rocepafant (BN 50730) is a specific platelet activating factor (PAF) antagonist. Rocepafant can be used in rheumatoid arthritis and nervous system research[1].
References
[1] Silva CL,et al. Formation of a highly stable complex between BN 50730 [tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methoxy-4 phenyl-carbamoyl)-9 pyrido [4',3'-4,5] thieno [3,2-f] triazolo-1,2,4 [4,3-a] diazepine-1,4] and the platelet-activating factor receptor in rabbit platelet membranes. Biochem Pharmacol. 1996 Jan 26;51(2):193-6. DOI:10.1016/0006-2952(95)02158-2
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