dihydrohonokiol Chemical Properties

InChI

InChI=1S/C18H20O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h4,7-12,19-20H,2-3,5-6H2,1H3

InChIKey

IBKNHHZQPPUDQJ-UHFFFAOYSA-N

SMILES

C1(C2=CC=C(O)C(CC=C)=C2)=CC(CCC)=CC=C1O

dihydrohonokiol Usage And Synthesis

Uses

Dihydrohonokiol B (Dihydrohonokiol) is an anxiolytic agent. Dihydrohonokiol B can reduce the neurotoxicity induced by amyloid β protein by stimulating the GABAC receptor. Dihydrohonokiol B can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1][2].

References

[1] Esumi T, et al. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. Bioorg Med Chem Lett. 2004 May 17;14(10):2621-5. DOI:10.1016/j.bmcl.2004.02.067
[2] Liu B, et al. Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons. Neurosci Lett. 2005 Aug 12-19;384(1-2):44-7. DOI:10.1016/j.neulet.2005.04.081