holomycin Chemical Properties

Melting point:

268 °C (decomp)

Boiling point:

532.1±50.0 °C(Predicted)

Density 

1.63±0.1 g/cm3(Predicted)

solubility 

DMSO, Methanol (Heated)

form 

Solid

pka

9.33±0.40(Predicted)

color 

Brown-Orange

Safety Information

Toxicity

LD50 i.v. in mice: 5-10 mg/kg (Von Daehne)

holomycin Usage And Synthesis

Uses

Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity.

Definition

ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049

holomycin(488-04-0)Related Product Information

• THIOLUTIN
• thiomarinol
• aureothricin
• holomycin