AK 295
AK 295 Basic information
- Product Name:
- AK 295
- Synonyms:
-
- Carbamic acid, N-[(1S)-1-[[[1-ethyl-3-[[3-(4-morpholinyl)propyl]amino]-2,3-dioxopropyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester
- CX 295
- CX295
- CX-295
- CAS:
- 160399-35-9
- MF:
- C26H40N4O6
- MW:
- 504.62
- Mol File:
- 160399-35-9.mol
More
Less
AK 295 Chemical Properties
- form
- Solid
- color
- White to off-white
More
Less
AK 295 Usage And Synthesis
Description
AK 295, also known asCX 295, is a dipeptide alpha-ketoamide calpain inhibitor.
Uses
AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis[1].
References
[1] Colak A, et al. Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats. Neurocirugia (Astur). 2009 Jun;20(3):245-54. PMID:19575128