SR 11237
SR 11237 Basic information
- Product Name:
- SR 11237
- Synonyms:
-
- SR 11237
- 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid
- 4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid
- BMS 188649
- BMS649
- Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-
- Retinoid X receptors,bone,BMS 649,transactivate,BMS649,Retinoic acid receptors,reporter,ossification,RAR/RXR,inhibit,Inhibitor,RXR/RXR,BMS-649,SR11237,homodimers,gene,SR-11237
- SR11237, 10 mM in DMSO
- CAS:
- 146670-40-8
- MF:
- C24H28O4
- MW:
- 380.48
- Mol File:
- 146670-40-8.mol
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SR 11237 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: >28mg/mL (warmed)
- form
- powder
- color
- white to off-white
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SR 11237 Usage And Synthesis
Uses
SR 11237 is a pan RXR agonist with without RAR activity. It is used in treatment of neurodegenerative diseases.
Biological Activity
Pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.
in vivo
SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate[2].
| Animal Model: | Sprague-Dawley rats[2] |
| Dosage: | 25 mg/kg |
| Administration: | I.p.; daily from post-natal days 5 to 15 |
| Result: | Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis. |
storage
Store at -20°C
SR 11237Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
Syntechem Co.,Ltd
- Tel
- info@syntechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com