MDL 72527
MDL 72527 Basic information
- Product Name:
- MDL 72527
- Synonyms:
-
- N,N'-di(buta-2,3-dien-1-yl)butane-1,4-diaMine
- CPC-200
- MDL 72527, >=97%
- MDL727527
- MDL 72527 (hydrochloride)
- MDL 72527
- N,N'-Bis(2,3-butadienyl)-1,4-butanediamine
- N,N'-Bis(2,3-butanedienyl)-1,4-butanediamine
- CAS:
- 93565-01-6
- MF:
- C12H20N2.2HCl
- MW:
- 0
- Mol File:
- 93565-01-6.mol
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MDL 72527 Chemical Properties
- Melting point:
- 236-237 °C (decomp)(Solv: ethanol (64-17-5); ethyl acetate (141-78-6))
- storage temp.
- Sealed in dry,2-8°C
- solubility
- H2O: soluble15mg/mL, clear
- form
- powder
- color
- light yellow to light brown
- Water Solubility
- H2O: 15mg/mL, clear
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MDL 72527 Usage And Synthesis
Uses
MDL 72527 is a lysosomotropic polyamineoxidase inhibitor.
Biological Activity
Polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo .
in vivo
MDL 72527 (100 mg/kg; i.p.; once) shows neuroprotective against neuronal cell damage after temporary focal cerebral ischemia[1].
| Animal Model: | 250-300 g, Male spontaneously hypertensive rats (SHRs)[1] |
| Dosage: | 100 mg/kg |
| Administration: | I.p.; after the induction of ischemia |
| Result: | Significantly reduced meanarterial blood pressure, changed the brain edema formation from 85.7 ± 0.3 to 84.5 ± 0.9% in cortex and from 79.9 ± 1.7 to 78.4 ± 2.0% in subcortex (difference not significant), reduced ischemic injury volume by 22% in the cortex and 17% in the subcortex. |
MDL 72527Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
- 3bsc@sina.com
Syntechem Co.,Ltd
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- info@syntechem.com
Hangzhou Yuhao Chemical Technology Co., Ltd
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- 0571-82693216
- info@yuhaochemical.com
Baiyin Chengze Chemical Technology Co., Ltd.
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- +86 943-8535351 13389336721
- sales@chengzechem.com
Nanjing Dulai Biotechnology Co., Ltd.
- Tel
- 025-846993838003-8003 18013301590
- njduly@126.com