1-bromocyclobutane-1-carboxylic acid Chemical Properties

Melting point:

48℃

Boiling point:

249℃

Density 

1.864

Flash point:

104℃

storage temp. 

Storage temp. 2-8°C

pka

2.94±0.20(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C5H7BrO2/c6-5(4(7)8)2-1-3-5/h1-3H2,(H,7,8)

InChIKey

YREQYUFYDFSXJC-UHFFFAOYSA-N

SMILES

C1(Br)(C(O)=O)CCC1

Safety Information

HS Code 

2916200090

1-bromocyclobutane-1-carboxylic acid Usage And Synthesis

Uses

1-Bromocyclobutane-1-carboxylic acid can serve as a key synthetic building block for constructing 1,1-diarylcyclobutane compounds. It is chosen as the optimal starting material due to its easy availability and the fact that it requires no protecting group.

References

[1] Massaro, L., Neigenfind, P., Feng, A., Kuehn, G., Attard, F. C., DeSanti, A., Collins, M. R., Bravo, M., Twumasi, R. K., Chen, D., Bolduc, P. N., Nicastri, M., Emmanuel, M. A., Oderinde, M. S., Palkowitz, M. D., Zheng, X., Hunter, A. C., Harper, K. C., Tyrol, C. C., … Baran, P. S. (2025). Triply convergent Ni-electrocatalytic assembly of 1,1-diaryl cyclobutanes, azetidines and oxetanes. <i>Nature Chemistry</i>, <i>18 2</i>, 326–334. https://doi.org/10.1038/s41557-025-01990-x