TERT-BUTYLSULFONAMIDE Chemical Properties

Melting point:

166.0 to 170.0 °C

Boiling point:

223.1±23.0 °C(Predicted)

Density 

1.149±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

10.93±0.60(Predicted)

color 

White to Almost white

CAS DataBase Reference

34813-49-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2935909099

TERT-BUTYLSULFONAMIDE Usage And Synthesis

Synthesis

The general procedure for the synthesis of tert-butylsulfonamide from tert-butylsulfonyl chloride is as follows: ammonia was vented into a solution of tetrahydrofuran (THF, 5 mL) containing tert-butylsulfonyl chloride (500 mg, 3.2 mmol) at -50 °C for 15 min. Subsequently, the reaction mixture was warmed to 20-35 °C and the reaction was continued with stirring for 16 hours. Upon completion of the reaction, the resulting solid precipitate was collected by filtration. The filtrate was concentrated under reduced pressure to give 350 mg of tert-butylsulfonamide. The product was characterized by 1H NMR (400 MHz, DMSO-d6) with chemical shifts of δ 6.71 (2H, broad peak) and 1.38 (9H, single peak).

References

[1] Patent: WO2013/88256, 2013, A1. Location in patent: Page/Page column 62
[2] Patent: US2014/371217, 2014, A1. Location in patent: Paragraph 0581

TERT-BUTYLSULFONAMIDE(34813-49-5)Related Product Information

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• TERT-BUTYLSULFONAMIDE