tert-Butanesulfinamide Chemical Properties

Melting point:

97-101 °C(lit.)

Boiling point:

220.0±23.0 °C(Predicted)

Density 

1.124

storage temp. 

2-8°C

solubility 

Soluble in methanol.

pka

10.11±0.50(Predicted)

form 

Powder or Crystals

color 

White to tan

CAS DataBase Reference

146374-27-8(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HS Code 

29309090

MSDS

• Language:English Provider:SigmaAldrich

tert-Butanesulfinamide Usage And Synthesis

Description

(S)-tert-Butanesulfinamide (also known as 2-Methyl-2-propanesulfinamide) is used for the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne.It can be also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfonylimine1,2-(R)-(+)-2-Methyl-2-propanesulfinamide may be used to prepare N-(1-cyclohexylmethylidene)-2-methylpropane-2-sulfinamide via copper mediated condensation with cyclohexane carboxaldehyde. It may also be used to prepare (20E)-N-[t-butyl-(R)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the development of androgen receptor antagonists. (S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents.

Chemical Properties

white to light yellow crystal powde

Uses

(±)-2-Methyl-2-propanesulfinamide is used in the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne. It is also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfonylimine.

Uses

Ellman′s Sulfinamides

tert-Butanesulfinamide(146374-27-8)Related Product Information

• Kresoxim-methyl
• 4-tert-Butylcatechol
• tert-Butyl acetate
• Di-tert-butyl peroxide
• tert-Butyl hydroperoxide
• METSULFURON METHYL
• Thiophanate-methyl
• tert-Butyldimethylsilyl chloride
• tert-Butyl peroxyacetate
• Pirimiphos-methyl
• Methyl acetate
• Methyl 4-tert-butylbenzoate
• 4-tert-Butylphenol
• tert-Butyl methyl ether
• Methyl salicylate
• tert-Butyllithium
• tert-Butanol
• Tribenuron methyl