XANTHOPTERIN Chemical Properties

Melting point:

410 C

Boiling point:

311.64°C (rough estimate)

Density 

1.5590

refractive index 

1.9900 (estimate)

storage temp. 

Store at -20°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

Solid

pka

6.59(at 20℃)

color 

Light yellow to brown

Water Solubility 

25mg/L(22.5 ºC)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

XANTHOPTERIN Usage And Synthesis

Uses

Xanthopterin, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin (XPT) causes renal growth and hypertrophy in rat[1]. Xanthopterin inhibits RNA synthesis[4].

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 4455, 1973 DOI: 10.1021/ja00794a071

References

[1] Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy. DOI:10.1159/000188363
[2] Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222(1):119-24. DOI:10.1016/j.canlet.2004.09.009
[3] Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis): light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85(4):955-61. DOI:10.1111/j.1751-1097.2008.00526.x
[4] Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365(6):667-73. DOI:10.1515/bchm2.1984.365.1.667

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