Basic information Safety Supplier Related

CYCLOPIAZONIC ACID

Basic information Safety Supplier Related

CYCLOPIAZONIC ACID Basic information

Product Name:
CYCLOPIAZONIC ACID
Synonyms:
  • -Cyclopiazonic acid / CPA
  • Cyclopiazonic acid from Penicillium grisefulvum
  • Cyclopiazonic acid (CPA)
  • Cyclopiazonic acid, FroM PenicilliuM griseofulvuM
  • (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
  • Cyclopiazonic acid, 98%, from Penicillium griseofulvum
  • Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem
  • (6a-alpha,11a,11b-alpha)--10-acetyl-7-dimethyl-11-hydroxy-
CAS:
18172-33-3
MF:
C20H20N2O3
MW:
336.38
Product Categories:
  • antibiotic
  • Signalling
  • Calcium signaling
Mol File:
18172-33-3.mol
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CYCLOPIAZONIC ACID Chemical Properties

Melting point:
245-246°C
Boiling point:
472.86°C (rough estimate)
Density 
1.2171 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
powder
pka
4.50±1.00(Predicted)
color 
white to off-white
Water Solubility 
Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
EPA Substance Registry System
Cyclopiazonic acid (18172-33-3)
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
UY8587000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29337900
Hazardous Substances Data
18172-33-3(Hazardous Substances Data)
Toxicity
chicken,LD50,oral,12mg/kg (12mg/kg),Poultry Science. Vol. 65(Suppl,

MSDS

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CYCLOPIAZONIC ACID Usage And Synthesis

Description

Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 μM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.

Chemical Properties

off-white powder or crystals

Uses

Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.

Uses

The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis. It is also used as an inhibitor of endoplasmic reticulum Ca2+-ATPase.

Uses

Cyclopiazonic acid from?Penicillium cyclopium has been used:

  • as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)
  • as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)
  • as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking
  • as an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+?during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA

General Description

Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species.

Biological Activity

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca 2+ -ATPase.

Biochem/physiol Actions

Inhibits the sarcoplasmic reticulum Ca2+-pump.

storage

-20°C

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