DCPIB Chemical Properties

Boiling point:

593.8±50.0 °C(Predicted)

Density 

1.262±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

insoluble in H2O; ≥49.8 mg/mL in EtOH; ≥50.8 mg/mL in DMSO

form 

solid

pka

4.53±0.10(Predicted)

color 

White

Safety Information

Hazard Codes 

T

Risk Statements 

25-41

Safety Statements 

26-36/39-45

DCPIB Usage And Synthesis

Uses

DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells.

Definition

ChEBI: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid is a member of indanones.

Biological Activity

Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β -cells (IC 50 ~ 2 μ M) and I Cl,swell in various cardiovascular tissues (IC 50 = 4.1 μ M in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl - and K + currents (< 10% inhibition at 10 μ M). Inhibits glucose-stimulated insulin secretion in intact β -cells via VSAC inhibition and indirect K ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro .

storage

Store at +4°C

DCPIB(82749-70-0)Related Product Information

• 2,3-Dichloro-4-hydroxybenzaldehyde
• 6-CHLORO-1-INDANONE 96
• 7-CHLORO-1-INDANONE
• 2-CHLORO-4,5-DIMETHYLPHENOL
• 4-(3-CHLORO-PHENOXY)-BUTYRIC ACID
• 2'-CHLORO-2,2-DIMETHYLBUTYROPHENONE
• 2',3'-DICHLORO-2,2-DIMETHYLBUTYROPHENONE
• 2-PENTYL-1-INDANONE
• 1-(3-chloro-4-ethoxyphenyl)ethanone
• DCPIB
• 1-(3-CHLORO-4-PROPOXYPHENYL)-ETHANONE
• 3'-CHLORO-2,2-DIMETHYLBUTYROPHENONE
• 2'-CHLORO-2,2-DIMETHYLPROPIOPHENONE
• 2',3'-DICHLORO-2,2-DIMETHYLPROPIOPHENONE
• 2,2-DIMETHYL-4'-METHOXYBUTYROPHENONE
• 4-(4-ACETYL-PHENOXY)-BUTYRIC ACID
• 1-(4-methoxyphenyl)-2,2-dimethyl-propan-1-one
• 3'-CHLORO-2,2-DIMETHYLPROPIOPHENONE