NF 023 Chemical Properties

storage temp. 

Desiccate at RT

solubility 

H₂O: >20 mg/mL

form 

crystalline

color 

white

Water Solubility 

Soluble to 100 mM in water

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

NF 023 Usage And Synthesis

Uses

NF 023 is a subtype selective, competitive and reversible P2X1 receptor antagonist.

Biological Activity

A subtype-selective, competitive and reversible P2X 1 receptor antagonist. Displays IC 50 values of 0.21, 28.9, > 50 and > 100 μ M for human P2X 1 , P2X 3 , P2X 2 , and P2X 4 -mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α -subunit of G o/i (EC 50 ~? 300 nM).

Biochem/physiol Actions

NF 023 contains six benzene rings and is a suramin analog. It is a potent, competitive, and selective P2X purinoceptor antagonist that aids in discriminating between P2X receptor subtypes.

storage

Desiccate at RT

NF 023(104869-31-0)Related Product Information

• 1,5-NAPHTHALENEDISULFONIC ACID DISODIUM SALT, DIHYDRATE, 98
• 1-Naphthylamine-4,6,8-trisulfonic acid
• Disodium 1,5-naphthalenedisulfonate
• 8-AMINO-1,5-NAPHTHALENEDISULFONIC ACID MONOSODIUM SALT
• NF 023
• sodium N-benzylsulphanilate
• Naphthalene-1,3,5-trisulphonic acid