Carzenide Chemical Properties

Melting point:

285-295 °C (lit.)

Boiling point:

449.0±47.0 °C(Predicted)

Density 

1.5083 (rough estimate)

refractive index 

1.6100 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

0.5g/l

form 

Powder

pka

3.50(at 25℃)

color 

White

Water Solubility 

453 mg/L (25 ºC)

Merck 

14,1876

BRN 

1875393

CAS DataBase Reference

138-41-0(CAS DataBase Reference)

NIST Chemistry Reference

P-sulfamoylbenzoic acid(138-41-0)

EPA Substance Registry System

4-Aminosulfonylbenzoic acid (138-41-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-20/21/22

Safety Statements 

22-24/25-36/37/39-26-36

WGK Germany 

3

RTECS 

DH6820000

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29163990

Toxicity

LD50 i.p. in rats: 350 ± 22 mg/kg (Appenroth, Brunlich)

MSDS

• Language:English Provider:Carzenide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Carzenide Usage And Synthesis

Description

4-Sulfamoylbenzoic acid is a significant class of compounds extensively investigated for their potential applications across various disciplines. Characterized by a nitrogen-containing ring structure, 4-Sulfamoylbenzoic acid is a heterocyclic compound adorned with diverse substituents encircling the ring. Within the body, 4-Sulfamoylbenzoic acid is an agonist for several receptors, including those for serotonin and dopamine. By forming connections with these receptors, 4-Sulfamoylbenzoic acid proficiently modulates their functionality, consequently inducing changes in receptor behavior. This, in turn, precipitates an array of effects contingent upon the specific receptor and the studied drug.

Chemical Properties

White powder

Uses

diuretic, carbonic anhydrase inhibitor

Uses

4-Sulfamoylbenzoic Acid (Carzenide) is used as a reagent in the synthesis of carbonic anhydrase inhibitors anticonvulsant agents.

Application

Carzenide is an antispasmodic that has been used in the treatment of dysmenorrhoea. Currently Carzenide is an organic synthesis intermediate, used for synthetic drug.

Definition

ChEBI: Carzenide is a sulfonamide.

reaction suitability

reagent type: cross-linking reagent

Synthesis

Example 11: In a 25 mL reaction vial, 1 mmol of p-carboxybenzenesulfonamide, 0.05 mmol of 3,5-dinitro-N-hydroxy-N-methylbenzamide, and 0.01 mmol of cobalt acetate were added, followed by the addition of 5 mL of acetic acid as solvent. The reaction system was placed in an oxygen atmosphere, maintaining an oxygen pressure of 1 atmosphere, and the temperature was raised to 100 °C. The reaction lasted for 10 hours. After completion of the reaction, the reaction mixture was cooled to room temperature. Recovery of acetic acid was achieved by removing acetic acid from the filtrate by distillation under reduced pressure. The residue was washed repeatedly with water to remove residual acetic acid and cobalt acetate co-catalyst, and then washed with a small amount of acetone to remove 3,5-dinitro-N-hydroxy-N-methylbenzamide and a small amount of p-hydroxymethylbenzenesulfonimide. The resulting filter cake was dried to give p-carboxybenzenesulfonamide. The yield of the reaction was 94.05%, the conversion of p-toluenesulfonamide was 99.33% and the selectivity of p-carboxybenzenesulfonamide was 94.68%. The product was analyzed by Agilent 1200 HPLC and the purity was 95.14%.

References

[1] Patent: CN105801455, 2016, A. Location in patent: Paragraph 0048
[2] Patent: US2004/58977, 2004, A1. Location in patent: Page/Page column 8; 14
[3] American Chemical Journal, 1885, vol. 7, p. 147
[4] Justus Liebigs Annalen der Chemie, 1875, vol. 178, p. 284
[5] Journal of the Chemical Society, 1951, p. 1877,1880

Carzenide(138-41-0)Related Product Information

• 4-Aminophenylacetic acid
• Terephthalic acid
• Ethyl 4-iodobenzoate
• N,N-DIETHYL-4-SULFAMOYLBENZOIC ACID
• Probenecid
• Halazone
• Carzenide
• Benzenesulfonamide
• p-Toluenesulfonamide
• Sulfanilamide
• Sulfamide
• CARBOXYTOLBUTAMIDE
• 4-Carboxytolbutamide Methyl Ester
• 4-DIMETHYLSULFAMOYL-BENZOIC ACID
• 4-[(FURAN-2-YLMETHYL)-SULFAMOYL]-BENZOIC ACID
• 4-[(4-methylpiperazin-1-yl)sulfonyl]benzoic acid
• 4-(PYRROLIDINE-1-SULFONYL)-BENZOIC ACID
• 4-CARBOXYBENZENESULFONYL AZIDE