2,6-DICHLOROPHENETHYLALCOHOL Chemical Properties

Melting point:

59-65 °C

Boiling point:

152 °C / 12mmHg

Density 

1.2559 (rough estimate)

refractive index 

1.5670 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

14.56±0.10(Predicted)

form 

Crystalline Powder, Crystals or Flakes

color 

White to slightly yellow

CAS DataBase Reference

30595-79-0(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29062990

MSDS

• Language:English Provider:ACROS

2,6-DICHLOROPHENETHYLALCOHOL Usage And Synthesis

Chemical Properties

white to slightly yellow crystalline powder,

Synthesis

(vii) Synthesis of 2,6-dichlorophenylethanol: A suspension of lithium aluminum hydride (13.75 g, 365.75 mmol) was slowly added to a solution of anhydrous ether (500 mL) containing 2,6-dichlorophenylacetic acid (50 g, 243.75 mmol) through a powder charging funnel under nitrogen protection. The reaction mixture was heated to reflux and maintained for 16 hours. Upon completion of the reaction, the reaction was quenched by slow dropwise addition of a saturated aqueous solution of sodium sulfate (25 mL). The resulting slurry was stirred at room temperature for 3 hours, followed by filtration through a Brinell funnel and washing the solid residue with ether (2 x 100 mL). The ether layer filtrates were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to give 38.6 g (85% yield) of 2,6-dichlorophenethyl alcohol as a colorless oil.

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 12, p. 2818 - 2841
[2] Patent: EP1087934, 2004, B1. Location in patent: Page 28
[3] Journal of Medicinal Chemistry, 1970, vol. 13, # 6, p. 1051 - 1057
[4] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 23, p. 5211 - 5217

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