2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Chemical Properties

Boiling point:

463.8±45.0 °C(Predicted)

Density 

1.416±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

Soluble to 20 mM in DMSO and to 5 mM in ethanol

form 

Black-purple solid

pka

-1.63±0.20(Predicted)

color 

Brown to black

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Usage And Synthesis

Uses

Ryuvidine is an antifungal agent used against pathogenic fungi.

Definition

ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.

General Description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC₅₀ = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC₅₀ = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE(265312-55-8)Related Product Information

• 1-(2-METHYL-1,3-THIAZOL-4-YL)ETHANONE
• 4,5-THIAZOLEDICARBOXALDEHYDE
• 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE