ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > Glycine derivative > Tubulysin A,TubA
Tubulysin A,TubA
Tubulysin A,TubA Basic information
- Product Name:
- Tubulysin A,TubA
- Synonyms:
-
- TubA
- Tubulysin A
- Tubulysin A,TubA
- Tubulysins A
- CS-1324
- Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
- (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci
- CAS:
- 205304-86-5
- MF:
- C43H65N5O10S
- MW:
- 844.07
- Mol File:
- 205304-86-5.mol
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Tubulysin A,TubA Chemical Properties
- Melting point:
- 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5))
- Boiling point:
- 979.9±65.0 °C(Predicted)
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- organic solvents: soluble
- form
- film
- pka
- 4.52±0.23(Predicted)
- color
- colorless or white
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Safety Information
- Hazard Codes
- T
- Risk Statements
- 23/24/25-36/37/38
- Safety Statements
- 36/37-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
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Tubulysin A,TubA Usage And Synthesis
Uses
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.
Definition
ChEBI: Tubulysin A is a diester and a carboxylic acid.
Biochem/physiol Actions
Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
Tubulysin A,TubASupplier
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