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Tubulysin A,TubA

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Tubulysin A,TubA Basic information

Product Name:
Tubulysin A,TubA
Synonyms:
  • TubA
  • Tubulysin A
  • Tubulysin A,TubA
  • Tubulysins A
  • CS-1324
  • Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl][(3-methyl-1-oxobutoxy)methyl]amino]pentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
  • (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoicaci
CAS:
205304-86-5
MF:
C43H65N5O10S
MW:
844.07
Mol File:
205304-86-5.mol
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Tubulysin A,TubA Chemical Properties

Melting point:
106-108 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point:
979.9±65.0 °C(Predicted)
Density 
1.195±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
organic solvents: soluble
form 
film
pka
4.52±0.23(Predicted)
color 
colorless or white
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25-36/37/38
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Tubulysin A,TubA Usage And Synthesis

Uses

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.

Definition

ChEBI: Tubulysin A is a diester and a carboxylic acid.

Biochem/physiol Actions

Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

Tubulysin A,TubASupplier

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