4-Imidazolemethanol hydrochloride Chemical Properties

Melting point:

110 °C

storage temp. 

2-8°C

solubility 

water: soluble50mg/mL, clear to slightly hazy, colorless to yellow

form 

crystalline

color 

off-white to yellow

Water Solubility 

Soluble in water.

BRN 

3562041

Stability:

Hygroscopic

CAS DataBase Reference

32673-41-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

F 

3

Hazard Note 

Irritant

HS Code 

29332900

MSDS

• Language:English Provider:4-Imidazolemethanol hydrochloride
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4-Imidazolemethanol hydrochloride Usage And Synthesis

Chemical Properties

light yellow to beige or light brown crystalline

Uses

Synthesis of imidazole-containing peptidomimetic inhibitors.1

Uses

4-Imidazolemethanol hydrochloride was used in the synthesis of imidazole-containing peptidomimetic inhibitors.

Synthesis

A solvent mixture of acetonitrile and ethanol with a volume ratio of 2:1 was added to the reactor, and 100 mmol of 1,3-dihydroxyacetone and 200 mmol of formaldehyde were added sequentially and stirred until complete dissolution. Subsequently, 100 mmol of ceric ammonium nitrate was added as an oxidizing agent. The pH of the reaction system was adjusted to 10 by slow dropwise addition of sodium ethanolate solution at atmospheric pressure and 60 °C, and 15 mmol of catalyst was added. The reaction was stirred under this condition for 8 hours, and 4-hydroxymethylimidazole was obtained after completion of the reaction. To the reaction solution, concentrated hydrochloric acid was added dropwise to adjust the pH to 2, and the precipitate was collected by filtration. The solid was washed with saturated sodium chloride solution and subsequently recrystallized with ethanol. Finally, the product was dried under vacuum to obtain 4-hydroxymethylimidazole hydrochloride. The purity of the product was determined to be 98.2% and the yield was 87.5%.

References

[1] Patent: CN106349165, 2017, A. Location in patent: Paragraph 0016-0030

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