2,6-dichloro-N-Methylpyridin-4-aMine Chemical Properties

Melting point:

70 °C

Boiling point:

312.0±37.0 °C(Predicted)

Density 

1.404±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

0.79±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

2,6-dichloro-N-Methylpyridin-4-aMine Usage And Synthesis

Synthesis

GENERAL STEPS: 2,4,6-Trichloropyridine (20.0 g, 109.63 mmol) was dissolved in anhydrous ethanol (100 mL). An ethanol solution of 33% methylamine (81.9 mL, 657 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred continuously at room temperature for 2 weeks. After completion of the reaction, the white precipitate was collected by filtration and washed with methyl tert-butyl ether and deionized water sequentially to afford 2,6-dichloro-4-methylaminopyridine (11.9 g, 61% yield) as white crystals.

References

[1] Patent: WO2008/92942, 2008, A2. Location in patent: Page/Page column 22
[2] Patent: WO2006/53166, 2006, A1. Location in patent: Page/Page column 57-58
[3] New Journal of Chemistry, 2016, vol. 40, # 11, p. 9194 - 9204
[4] Patent: WO2006/122137, 2006, A1. Location in patent: Page/Page column 71-72
[5] Patent: US2015/57260, 2015, A1. Location in patent: Paragraph 0300; 0331; 0551; 0552

2,6-dichloro-N-Methylpyridin-4-aMine(175461-33-3)Related Product Information

• Pyridine,2-chloro-6-fluoro-4-Methyl
• [1,3]THIAZOLO[5,4-B]PYRIDINE