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BET-BAY-002

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BET-BAY-002 Basic information

Product Name:
BET-BAY-002
Synonyms:
  • BET-BAY 002
  • BET-BAY-002
  • (4R)-6-(4-Chlorophenyl)-1-methyl-4-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-4H-[1,2,4]triazolo[4,3-a][1]benzazepine
  • 4H-[1,2,4]Triazolo[4,3-a][1]benzazepine, 6-(4-chlorophenyl)-1-methyl-4-[(5-methyl-1,3,4-oxadiazol-2-yl)methyl]-, (4R)-
  • BET BAY 002,BETBAY 002
CAS:
1588521-78-1
MF:
C22H18ClN5O
MW:
403.86
Mol File:
1588521-78-1.mol
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BET-BAY-002 Chemical Properties

Boiling point:
635.7±65.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 50 mg/mL (123.81 mM)
pka
2.44±0.60(Predicted)
form 
Powder
color 
White to off-white
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BET-BAY-002 Usage And Synthesis

Uses

BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.

References

[1] Evans DM,?et al. Exposure?time?versus?cytotoxicity?for?anticancer agents.Cancer Chemother Pharmacol.?2019 Aug;84(2):359-371. DOI:10.1007/s00280-019-03863-w
[2] Jung M,?et al. Targeting?BET?bromodomains?for?cancer?treatment. Epigenomics.?2015;7(3):487-501. DOI:10.2217/epi.14.91

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