11(R)-HEPE Chemical Properties

Boiling point:

488.0±45.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

pka

4.75±0.10(Predicted)

InChIKey

IDEHSDHMEMMYIR-DJWFCICMSA-N

SMILES

C(O)(=O)CCC/C=C\C/C=C\C[C@@H](O)/C=C/C=C\C/C=C\CC

11(R)-HEPE Usage And Synthesis

Description

11(R)-HEPE is produced by the oxidation of EPA by 11(R)-LO. This enzymatic activity and the resulting 11(R)-hydroxy acid have been isolated from the sea urchin S. purpuratus.

Uses

11(R)-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid)[1].

Definition

ChEBI: 11(R)-HEPE is an 11-HEPE that consists of (5Z,8Z,12E,14Z,17Z)-icosapentaenoic acid in which the hydroxy group is located at the 11R-position. It has a role as a human xenobiotic metabolite, an anti-inflammatory agent and an algal metabolite. It is a conjugate acid of an 11(R)-HEPE(1-).

References

[1] Di Marzo V, et al. Polyunsaturated-fatty-acid oxidation in Hydra: regioselectivity, substrate-dependent enantioselectivity and possible biological role. Biochem J. 1994 Jun 1;300 ( Pt 2)(Pt 2):501-7. DOI:10.1042/bj3000501

11(R)-HEPE(109430-11-7)Related Product Information

• (+/-)-11-HYDROXY-5Z,8Z,12E,14Z,17Z-EICOSAPENTAENOIC ACID
• 11(R)-HEPE