(+/-)-11-HYDROXY-5Z,8Z,12E,14Z,17Z-EICOSAPENTAENOIC ACID Chemical Properties

Boiling point:

488.0±45.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

solubility 

0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml

pka

4.75±0.10(Predicted)

(+/-)-11-HYDROXY-5Z,8Z,12E,14Z,17Z-EICOSAPENTAENOIC ACID Usage And Synthesis

Description

(±)11-HEPE is produced by non-enzymatic oxidation of eicosapentaenoic acid. It contains equal amounts of 11(S)-HEPE and 11(R)-HEPE. The biological activity of (±)11-HEPE has not been clearly documented.

Uses

11-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid)[1].

Definition

ChEBI: 11-HEPE is a HEPE that consists of (5Z,8Z,12E,14Z,17Z)-icosapentaenoic acid in which the hydroxy group is located at position 11. It has a role as a rat metabolite. It is functionally related to an all-cis-5,8,11,14,17-icosapentaenoic acid.

References

[1] Kogure R, et al. 5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):58-63. DOI:10.1016/j.bbrc.2011.10.141

(+/-)-11-HYDROXY-5Z,8Z,12E,14Z,17Z-EICOSAPENTAENOIC ACID(99217-78-4)Related Product Information

• 11(S)-HEPE
• 11(R)-HEPE
• (+/-)-11-HYDROXY-5Z,8Z,12E,14Z,17Z-EICOSAPENTAENOIC ACID