5-CHLORO-2-NITROANISOLE Chemical Properties

Melting point:

70-72 °C(lit.)

Boiling point:

289.1±20.0 °C(Predicted)

Density 

1.4219 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Ethyl Acetate

form 

Solid

color 

Yellow

CAS DataBase Reference

6627-53-8(CAS DataBase Reference)

EPA Substance Registry System

5-Chloro-2-nitroanisole (6627-53-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

HS Code 

2909309090

MSDS

• Language:English Provider:SigmaAldrich

5-CHLORO-2-NITROANISOLE Usage And Synthesis

Chemical Properties

SLIGHTLY YELLOW TO GREEN CRYSTALLINE POWDER

Uses

5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs (1). In addition, it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells (2).

Uses

5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs. In addition it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells.

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