2,5-Dimethylindole Chemical Properties

Melting point:

112-113 °C (lit.)

Boiling point:

254.33°C (rough estimate)

Density 

1.0353 (rough estimate)

refractive index 

1.5000 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

form 

Solid

pka

17.75±0.30(Predicted)

color 

Off-white to pale pink or light brown

CAS DataBase Reference

1196-79-8(CAS DataBase Reference)

NIST Chemistry Reference

1H-indole, 2,5-dimethyl-(1196-79-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41

Safety Statements 

26-39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29339900

MSDS

• Language:English Provider:2,5-Dimethylindole
• Language:English Provider:SigmaAldrich

2,5-Dimethylindole Usage And Synthesis

Description

2, 5-Dimethylindole is a kind of carbazole-system derived indole compound, which is valuable in the manufacturing of perfume. It is also a useful chemical intermediate. It is usually used as reactant in the following reaction: stereoselective synthesis of indolines via palladium-catalyzed asymmetric hydrogenation of unprotected indoles; stereoselective preparation of substituted indoles via rhodium-catalyzed enantioselective coupling reaction of indoles with diazo compounds; enantioselective synthesis of fluorene derivatives via Friedel-Crafts reactions; preparation of bis-indolyldihydroxybenzoquinones by addition indoles to dichlorobenzoquinone promoted by Bronsted acid; Reaction with hydroxypyrazolines.

Sources

https://www.sigmaaldrich.com/catalog/product/aldrich/d166006?lang=en&region=US
https://books.google.com/books?isbn=0470188073

Chemical Properties

Off-white to pale pink or light brown solid

Uses

• Reactant in stereoselective preparation of substituted indoles via rhodium-catalyzed enantioselective coupling reaction of indoles with diazo compounds
• Reactant in stereoselective synthesis of indolines via palladium-catalyzed asymmetric hydrogenation of unprotected indoles
• Reactant in enantioselective synthesis of fluorene derivatives via Friedel-Crafts reactions
• Reactant in preparation of bis-indolyldihydroxybenzoquinones by addition indoles to dichlorobenzoquinone promoted by Bronsted acid
• Reactant in reaction with hydroxypyrazolines

2,5-Dimethylindole(1196-79-8)Related Product Information

• dimebolin
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• 2,5-Dimethylindole
• 5-METHYLINDOLE-2-CARBOXYLIC ACID
• 5-ETHYLINDOLE-2-CARBOXYLIC ACID
• ETHYL 5-METHYLINDOLE-2-CARBOXYLATE
• 1,2-DIMETHYLINDOLE-3-CARBOXYLIC ACID
• 2,3-DIMETHYLINDOLE,2,3-DIMETHYLINDOLE, 97+%
• ETHYL 5-ACETYLOXY-1,2-DIMETHYLINDOLE-3-CARBOXYLATE,ETHYL5-ACETOXY-1,2-DIMETHYLINDOLE-3-CARBOXYLATE
• N,N-DIMETHYLINDOLINE-5-SULFONAMIDE
• 4,6-DIMETHYLINDOLE
• ETHYL5-HYDROXY-1,2DIMETHYLINDOLE-3-CARBOXYLATE
• 5-Fluoro-2,3-dimethyl-1H-indole
• 1,3-dimethylindole
• 1,2-Dimethylindole-3-carboxaldehyde
• 1,2-DIMETHYLINDOLE,Dimethylindole
• 1,2-Dimethylindole-3-carbonitrile,3-CYANO-1,2-DIMETHYLINDOLE
• 5-METHOXY-1,2-DIMETHYLINDOLE