ETHYL 5-METHYLINDOLE-2-CARBOXYLATE Chemical Properties

Melting point:

162-164°C

Boiling point:

236°C 4mm

Density 

1.177±0.06 g/cm3(Predicted)

Flash point:

236°C/4mm

storage temp. 

Sealed in dry,Room Temperature

pka

15.19±0.30(Predicted)

form 

crystalline powder

color 

Light yellow to beige

Water Solubility 

Soluble in methanol, and dichloromethane. Insoluble in water.

BRN 

159437

CAS DataBase Reference

16382-15-3(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2933998090

MSDS

• Language:English Provider:ALFA

ETHYL 5-METHYLINDOLE-2-CARBOXYLATE Usage And Synthesis

Uses

Reactant for synthesis of oxazino[4,3-a]indoles via cascade addition-cyclization reactions 1 Reactant for preparation of indolecarboxamides as cannabinoid CB1 receptor antagonists 2 Reactant for preparation of indole-3-propionic acids as antiinflammatory and analgesic agents 3 Reactant for Friedel-Crafts acylation with nitrobenzoyl chloride 4 Reactant for oximation reactions 5

Uses

Reactant for synthesis of oxazino[4,3-a]indoles via cascade addition-cyclization reactions, reactant for preparation of indolecarboxamides as cannabinoid CB1 receptor antagonists, reactant for preparation of indole-3-propionic acids as antiinflammatory and analgesic agents, reactant for Friedel-Crafts acylation with nitrobenzoyl chloride. Indole ring system is an important building block or intermediate in the synthesis of many pharmaceutical agents. It is formed during the Fischer indolization of ethyl pyruvate 2-[2-(methanesulfonyloxy)-4-methyl]phenylhydrazine. ? Reactant for oximation reactions

General Description

Ethyl 5-methylindole-2-carboxylate (5-Methylindole-2-carboxylic acid ethyl ester) is an indole derivative. Indole ring system is an important building block or intermediate in the synthesis of many pharmaceutical agents. It is formed during the Fischer indolization of ethyl pyruvate 2-[2-(methanesulfonyloxy)-4-methyl]phenylhydrazine.

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