Anti-Interleukin-28A Chemical Properties

storage temp. 

-20°C

form 

lyophilized

color 

white to off-white

biological source

rabbit

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Anti-Interleukin-28A Usage And Synthesis

Biological Activity

IFN-λ 2 (Ifnl2) belongs to the type III interferon (IFN-λ) family of proteins. It is associated with antiviral, antitumor and immune activities. In a retinal autoimmunity mouse model, Ifnl2 increases the autoimmune disease. Ifnl2 signals via IFN (interferon)-λ receptor complex consisting of IL-10Rβ (interleukin 10 receptor β) and the IL-28Rα chains. The signaling pathway involves JAK1 (Janus kinase 1)/TYK2 (non-receptor tyrosine-protein kinase) tyrosine kinases, transcription factor complex IFN-stimulated gene factor 3 containing STAT1 (signal transducer and activator of transcription 1), STAT2 and IFN regulatory factor (IRF)-9.
Recombinant murine IFN-l2 is a 19.8kDa protein containing 175 amino acid residues.