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Tenapanor

Basic information Safety Supplier Related

Tenapanor Basic information

Product Name:
Tenapanor
Synonyms:
  • Tenapanor
  • Rovatirelin Hydrate
  • Tenapanor(free base)
  • AZD-1722; AZD 1722; AZD1722; RDX 5791; RDX-5791; RDX5791; TENAPANOR FREE BASE; IBSRELA.
  • Ibsrela.
  • Tenapanor (AZD1722，RDX5791)
  • CS-2459
  • AZD1722
CAS:
1234423-95-0
MF:
C50H66Cl4N8O10S2
MW:
1145.04
Mol File:
1234423-95-0.mol
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Tenapanor Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (43.67 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
color 
White to off-white
InChIKey
DNHPDWGIXIMXSA-KQPQOZEFNA-N
SMILES
ClC1C=C(Cl)C=C2[C@H](C3C=CC=C(S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(C4C=CC=C([C@@H]5CN(C)CC6=C(C=C(Cl)C=C56)Cl)C=4)(=O)=O)C=3)CN(C)CC=12 |&1:7,52,r|
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Tenapanor Usage And Synthesis

Uses

Tenapanor is a medicine. This drug targets Nsp16 protein may corroborates a promising approach to combat SARS-CoV-2 virus.

in vivo

Tenapanor (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats[1].
? Tenapanor (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats[2].

Animal Model:Rats (intestinal loop model)[1]
Dosage:0.15, 0.5 mg/kg
Administration:P.o.
Result:Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum.
Animal Model:8 weeks, 250 g male Sprague–Dawley rats[2]
Dosage:0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt))
Administration:Oral gavage; twice-daily for 11 consecutive days
Result:Significantly augmented the reduction in urinary phosphorus excretion.

TenapanorSupplier

Nanjing Becas pharmatech Ltd. Gold
Tel
13912903754
Email
info@becaspharma.com
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Email
wtx@bayeebio.com
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
MedChemexpress LLC
Tel
021-58955995
Email
sales@medchemexpress.cn
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com