m-PEG7-aldehyde
m-PEG7-aldehyde Basic information
- Product Name:
- m-PEG7-aldehyde
- Synonyms:
-
- m-PEG7-aldehyde
- MPEG7-ALD
- mPEG7-CHO
- m-PEG9-aldehyde
- MPEG7-CH2CH2CHO
- mPEG7-pAld
- m-PEG6-CH2CH2CHO
- 4,7,10,13,16,19,22-Heptaoxatricosanal
- CAS:
- 1058691-77-2
- MF:
- C16H32O8
- MW:
- 352.42
- Mol File:
- 1058691-77-2.mol
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m-PEG7-aldehyde Chemical Properties
- solubility
- Soluble in Water, DMSO, DCM, DMF
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m-PEG7-aldehyde Usage And Synthesis
Description
m-PEG7-aldehyde is a PEG reagent containing an aldehyde group. Aldehyde can react with hydrazide and aminooxy groups for labeling and crosslinking carbonyls.
Biological Activity
M-PEG7-aldehyde is a non-cleavable ADC linker for antibody drug conjugate (ADC) synthesis,it is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Non-cleavable < span> | PEGs
|
m-PEG7-aldehydeSupplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
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Hunan HuaTeng Pharmaceutical Co., Ltd.,
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Borenpharm Co., Ltd
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Zhengzhou Acme Chemical Co., Ltd.
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