mPEG6-CH2COOH Chemical Properties

Boiling point:

455.8±40.0 °C(Predicted)

Density 

1.123±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

3.39±0.10(Predicted)

color 

Light yellow to yellow

mPEG6-CH2COOH Usage And Synthesis

Description

m-PEG7-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

mPEG6-CH2COOH(75427-75-7)Related Product Information

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