N-Acetyl-Calicheamicin
N-Acetyl-Calicheamicin Basic information
- Product Name:
- N-Acetyl-Calicheamicin
- Synonyms:
-
- N-Acetyl-Calicheamicin
- N-acetylcalicheamicin γ1
- N-acetyl-calicheamidn y1
- N-Acetyl-Calicheamicin g1
- Carbamic acid, [(1R,4Z,8S,13E)-8-[[2-O-[4-(acetylethylamino)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-dideoxy-4-S-[4-[(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl]-4-thio-β-D-ribo-hexopyranosyl]oxy]amino]-β-D-glucopyranosyl]oxy]-1-hydr...
- N-Acetyl-Calicheamicin γ|||N-Acetyl-γ-calicheamicin
- N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ)
- CAS:
- 108212-76-6
- MF:
- C57H76IN3O22S4
- MW:
- 1410.38
- Mol File:
- 108212-76-6.mol
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N-Acetyl-Calicheamicin Chemical Properties
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 7.13±0.60(Predicted)
- color
- White to off-white
- InChIKey
- WPDOZYZAJKUVRZ-VEKKAAIHNA-N
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N-Acetyl-Calicheamicin Usage And Synthesis
Description
N-Acetyl-Calicheamicin is a potent enediyne antitumor antibiotic.
Uses
N-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC[1].
References
[1] K C Nicolaou, et al. Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118. DOI:10.1073/pnas.2107042118
[2] Breanna S Vollmar, et al. Calicheamicin Antibody-Drug Conjugates with Improved Properties. Mol Cancer Ther. 2021 Jun;20(6):1112-1120. DOI:10.1158/1535-7163.MCT-20-0035
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