HO-PEG10-CH2COOH Chemical Properties

Boiling point:

604.7±50.0 °C(Predicted)

Density 

1.154±0.06 g/cm3(Predicted)

pka

3.39±0.10(Predicted)

HO-PEG10-CH2COOH Usage And Synthesis

Biological Activity

HO-PEG10-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HO-PEG10-CH2COOH(2250056-53-0)Related Product Information

• HO-PEG11-CH2-COOH
• HO-PEG10-CH2CH2COOH
• Hydroxy-PEG12-acid
• HO-PEG12-CH2COOH
• Hydroxy-PEG11-acid