HO-PEG10-CH2CH2COOH
HO-PEG10-CH2CH2COOH Basic information
- Product Name:
- HO-PEG10-CH2CH2COOH
- Synonyms:
-
- HO-PEG10-CH2CH2COOH
- PROTAC Linkers,ADC Linkers,Inhibitor,inhibit,Hydroxy PEG10 acid,Antibody-drug conjugates linkers,Hydroxy-PEG-10-acid,HydroxyPEG10acid
- Propanoic acid, 3-[(29-hydroxy-3,6,9,12,15,18,21,24,27-nonaoxanonacos-1-yl)oxy]-
- 1-Hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oic acid
- CAS:
- 2375611-66-6
- MF:
- C23H46O13
- MW:
- 530.6
- Mol File:
- 2375611-66-6.mol
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HO-PEG10-CH2CH2COOH Chemical Properties
- Boiling point:
- 614.7±55.0 °C(Predicted)
- Density
- 1.143±0.06 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
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HO-PEG10-CH2CH2COOH Usage And Synthesis
Biological Activity
Hydroxy-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HO-PEG10-CH2CH2COOHSupplier
Xi'an Confluore Biological Technology Co., Ltd.
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TargetMol Chemicals Inc.
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Beijing Jin Ming Biotechnology Co., Ltd.
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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