HO-PEG10-CH2CH2COOH
HO-PEG10-CH2CH2COOH Basic information
- Product Name:
- HO-PEG10-CH2CH2COOH
- Synonyms:
-
- HO-PEG10-CH2CH2COOH
- PROTAC Linkers,ADC Linkers,Inhibitor,inhibit,Hydroxy PEG10 acid,Antibody-drug conjugates linkers,Hydroxy-PEG-10-acid,HydroxyPEG10acid
- Propanoic acid, 3-[(29-hydroxy-3,6,9,12,15,18,21,24,27-nonaoxanonacos-1-yl)oxy]-
- 1-Hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oic acid
- CAS:
- 2375611-66-6
- MF:
- C23H46O13
- MW:
- 530.6
- Mol File:
- 2375611-66-6.mol
More
Less
HO-PEG10-CH2CH2COOH Chemical Properties
- Boiling point:
- 614.7±55.0 °C(Predicted)
- Density
- 1.143±0.06 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
More
Less
HO-PEG10-CH2CH2COOH Usage And Synthesis
Biological Activity
Hydroxy-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HO-PEG10-CH2CH2COOHSupplier
Xi'an Confluore Biological Technology Co., Ltd.
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
Guangzhou Hongyuan Chemical Co.,Ltd
- Tel
- 15817493340
- 981810490@qq.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
Bide Pharmatech Ltd.
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com