MRT-83 hydrochloride Chemical Properties

storage temp. 

4°C, away from moisture

solubility 

DMSO : 250 mg/mL (434.74 mM; Need ultrasonic)

form 

Solid

color 

White to off-white

MRT-83 hydrochloride Usage And Synthesis

Biological Activity

MRT-83 (hydrochloride) is the potent antagonist of Smoothened (Smo) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease[1]. MRT-83 (hydrochloride) (compound 86) has IC50s of 15 and 11 nM respectively in Shh-light2 and C3H10T1/2 cells in the biological activity assay[1].

References

[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012;55(4):1559-1571.