JNJ-42259152 Chemical Properties

Melting point:

138.8 °C

Boiling point:

558.0±50.0 °C(Predicted)

Density 

1.19±0.1 g/cm3(Predicted)

pka

4.37±0.32(Predicted)

JNJ-42259152 Usage And Synthesis

Uses

JNJ-42259152 is a phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer that is specific for PDE10A activity. JNJ-42259152 can be dynamically scanned in healthy volunteers to assess its kinetic properties in the brain. The half-life of JNJ-42259152 in the blood is an average of 90 minutes. JNJ-42259152 has demonstrated reliable binding potential (BPND) in different target areas (such as the lentiform nucleus, caudate nucleus, ventral striatum, etc.), providing an important tool for studying neuropsychiatric diseases[1].

References

[1] Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test-retest study in human brain DOI:10.2967/jnumed.112.118679