5'-Azido-5'-deoxy-5-methyluridine Usage And Synthesis

Uses

5’-Azido-5’-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5’-Azido-5’-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

5'-Azido-5'-deoxy-5-methyluridine(1187022-65-6)Related Product Information

• 3',5'-Anhydrothymidine
• 3'-DEOXY-5-METHYLURIDINE
• 5-(Hydroxymethyl)uridine
• 5'-AMINO-5'-DEOXYTHYMIDINE
• NSC98948-d3